Physicians have long recognized the value of cold for reducing inflammation and relieving pain. Over time, they found that it is also an effective way to destroy specific tissues in a targeted way, a process called cryosurgery or cryoablation. Cryosurgery has been used since the 19th century to treat a variety of conditions, including warts, shingles, boils, and tumors. Today, cryoablation shows growing potential for the successful treatment of a variety of cancers as well as precancerous conditions.